Ion channels and their role in the pathophysiology of gliomas

T Takayasu, K Kurisu, Y Esquenazi… - Molecular cancer …, 2020 - AACR
Cell volume changes through the regulation of ion flux, … increased understanding of the
contributions of ion channels … form an amiloride-sensitive nonselective cation channel. The …

Ion channels as therapeutic targets in high grade gliomas

M Griffin, R Khan, S Basu, S Smith - Cancers, 2020 - mdpi.com
sodium channels (ENaC) are a class of amiloride-sensitive … of human glioma biopsies found
that higher grade gliomas … in glioma cell division, likely because of its regulatory effect on …

Ion channels in gliomas—from molecular basis to treatment

AF Elias, BC Lin, BJ Piggott - International Journal of Molecular Sciences, 2023 - mdpi.com
… for ASIC1 in glioma cell volume regulation in response to a … at the invadopodium of D54
human glioma cells [16,17]. Blocking … to form an amiloride-sensitive nonselective cation channel. …

Mambalgin-2 induces cell cycle arrest and apoptosis in glioma cells via interaction with ASIC1a

M Bychkov, M Shulepko, D Osmakov, Y Andreev… - Cancers, 2020 - mdpi.com
… can participate in the regulation of glioblastoma cell … the amiloride-sensitive ASIC1a channels
in glioma U251 MG … Our data suggest that mambalgin-2 inhibits the growth of glioma cells

… and Glyceraldehyde-3-Phosphate Dehydrogenase-Dependent Regulation of Epithelial Sodium Channels in hPheo1 Wild-type and SDHB Knockdown Cells

N Bala, L Yu, LP Liu, L Shelton, Y Xu… - …, 2023 - academic.oup.com
… in glioma cells (10); contribute to increased proliferation and … cancer cell behavior have
focused on changes in cell volume. … to contribute to amiloride-sensitive current in cancer cells (39)…

The Role of Ion-Transporting Proteins in Human Disease

Y Marunaka - International Journal of Molecular Sciences, 2024 - mdpi.com
… Potentiators such as ivacaftor increase the probability of the channel being open, … regulation
by controlling the volume of bodily fluids [28]. Amiloride-sensitive epithelial Na + channels in …

Capsazepine activates amiloride-insensitive ENaC-like channels in human leukemia cells

DV Lysikova, VY Vasileva… - Biochemical and …, 2023 - Elsevier
… main regulators of water-salt and volume balance in cells of … by benzamil and no
amiloride-sensitive component of recorded … ASIC1, as it was previously shown in human glioma

Epithelial sodium channels in macrophage migration and polarization: Role of proinflammatory cytokines TNFα and IFNγ

Z Nemeth, E Hildebrandt, N Parsa… - … -Regulatory …, 2022 - journals.physiology.org
… We found that IFNγ increased the phagocytosis of … ENaC contributed to this stimulated
response, we examined the amiloride (1 µM) sensitivity (Fig. 3C) and found the amiloride-sensitive

Novel ion channel targets and drug delivery tools for controlling glioblastoma cell invasiveness

A Varricchio, SA Ramesh, AJ Yool - International Journal of Molecular …, 2021 - mdpi.com
… in glioma cells increased motility by upregulating RhoC (a … [22] that is expressed in human
glioma biopsies [24]. The … channel ClC-3, also disrupting glioma cell volume regulation [131], …

Ion channels as therapeutic targets in high grade gliomas

S Smith, M Griffin, R Khan - Cancers - nottingham-repository.worktribe.com
sodium channels (ENaC) are a class of amiloride-sensitive … in glioma cell division, likely
because of its regulatory effect on … channel 3 expression increases sensitivity of human glioma