Ion channels and their role in the pathophysiology of gliomas
T Takayasu, K Kurisu, Y Esquenazi… - Molecular cancer …, 2020 - AACR
… Cell volume changes through the regulation of ion flux, … increased understanding of the
contributions of ion channels … form an amiloride-sensitive nonselective cation channel. The …
contributions of ion channels … form an amiloride-sensitive nonselective cation channel. The …
Ion channels as therapeutic targets in high grade gliomas
M Griffin, R Khan, S Basu, S Smith - Cancers, 2020 - mdpi.com
… sodium channels (ENaC) are a class of amiloride-sensitive … of human glioma biopsies found
that higher grade gliomas … in glioma cell division, likely because of its regulatory effect on …
that higher grade gliomas … in glioma cell division, likely because of its regulatory effect on …
Ion channels in gliomas—from molecular basis to treatment
AF Elias, BC Lin, BJ Piggott - International Journal of Molecular Sciences, 2023 - mdpi.com
… for ASIC1 in glioma cell volume regulation in response to a … at the invadopodium of D54
human glioma cells [16,17]. Blocking … to form an amiloride-sensitive nonselective cation channel. …
human glioma cells [16,17]. Blocking … to form an amiloride-sensitive nonselective cation channel. …
Mambalgin-2 induces cell cycle arrest and apoptosis in glioma cells via interaction with ASIC1a
… can participate in the regulation of glioblastoma cell … the amiloride-sensitive ASIC1a channels
in glioma U251 MG … Our data suggest that mambalgin-2 inhibits the growth of glioma cells …
in glioma U251 MG … Our data suggest that mambalgin-2 inhibits the growth of glioma cells …
… and Glyceraldehyde-3-Phosphate Dehydrogenase-Dependent Regulation of Epithelial Sodium Channels in hPheo1 Wild-type and SDHB Knockdown Cells
… in glioma cells (10); contribute to increased proliferation and … cancer cell behavior have
focused on changes in cell volume. … to contribute to amiloride-sensitive current in cancer cells (39)…
focused on changes in cell volume. … to contribute to amiloride-sensitive current in cancer cells (39)…
The Role of Ion-Transporting Proteins in Human Disease
Y Marunaka - International Journal of Molecular Sciences, 2024 - mdpi.com
… Potentiators such as ivacaftor increase the probability of the channel being open, … regulation
by controlling the volume of bodily fluids [28]. Amiloride-sensitive epithelial Na + channels in …
by controlling the volume of bodily fluids [28]. Amiloride-sensitive epithelial Na + channels in …
Capsazepine activates amiloride-insensitive ENaC-like channels in human leukemia cells
DV Lysikova, VY Vasileva… - Biochemical and …, 2023 - Elsevier
… main regulators of water-salt and volume balance in cells of … by benzamil and no
amiloride-sensitive component of recorded … ASIC1, as it was previously shown in human glioma …
amiloride-sensitive component of recorded … ASIC1, as it was previously shown in human glioma …
Epithelial sodium channels in macrophage migration and polarization: Role of proinflammatory cytokines TNFα and IFNγ
Z Nemeth, E Hildebrandt, N Parsa… - … -Regulatory …, 2022 - journals.physiology.org
… We found that IFNγ increased the phagocytosis of … ENaC contributed to this stimulated
response, we examined the amiloride (1 µM) sensitivity (Fig. 3C) and found the amiloride-sensitive …
response, we examined the amiloride (1 µM) sensitivity (Fig. 3C) and found the amiloride-sensitive …
Novel ion channel targets and drug delivery tools for controlling glioblastoma cell invasiveness
… in glioma cells increased motility by upregulating RhoC (a … [22] that is expressed in human
glioma biopsies [24]. The … channel ClC-3, also disrupting glioma cell volume regulation [131], …
glioma biopsies [24]. The … channel ClC-3, also disrupting glioma cell volume regulation [131], …
Ion channels as therapeutic targets in high grade gliomas
S Smith, M Griffin, R Khan - Cancers - nottingham-repository.worktribe.com
… sodium channels (ENaC) are a class of amiloride-sensitive … in glioma cell division, likely
because of its regulatory effect on … channel 3 expression increases sensitivity of human glioma …
because of its regulatory effect on … channel 3 expression increases sensitivity of human glioma …